The Scientific Advisory Committee (SAC) will coordinate the advising and monitoring of Center junior faculty investigators and the advising and monitoring of all ongoing studies. The SAC will base decisions about resource allocation, continued ongoing funding, and renewal of funded projects on assessments of the investigator and study progress. If a funded project is encountering difficulties, the SAC will work with the investigator to resolve these difficulties and if this is not possible, with making a decision about terminating funding.